Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
sigma_genes_megan	aging_gene	1.22e-02	3.34e-03	6.70e-24	7.82e-25
aging_gene	sigma_genes_megan	1.29e-04	6.00e-01	4.93e-03	1.93e-03



Evaluating how well sigma_genes_megan genes are linked to aging_gene genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_genes_megan	aging_gene	0.67	-0.26	-2.45	-2.01	11.59
aging_gene	sigma_genes_megan	0.39	-2.85	-0.65	-0.66	-4.42

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
sigma_genes_megan	aging_gene	0.02	-0.53	-3.48	-1.63	8.97
aging_gene	sigma_genes_megan	0.00	-2.83	-0.79	-0.37	-2.34

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
sigma_genes_megan	118	115	CTD-3088G3.8;AKR7L;PKD1L2
aging_gene	307	305	TERC;TOP 1.00