Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
118_sigma_genes	old_genes_UKB_lifespan	2.87e-01	7.78e-01	3.35e-03	8.04e-01
old_genes_UKB_lifespan	118_sigma_genes	3.04e-01	1.50e-01	2.23e-01	6.83e-03



Evaluating how well 118_sigma_genes genes are linked to old_genes_UKB_lifespan genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
118_sigma_genes	old_genes_UKB_lifespan	0.48	-0.23	-0.71	-0.10	-0.79
old_genes_UKB_lifespan	118_sigma_genes	0.43	-0.10	0.07	0.11	-2.71

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
118_sigma_genes	old_genes_UKB_lifespan	0.01	0.39	-0.24	0.50	-0.28
old_genes_UKB_lifespan	118_sigma_genes	0.01	-0.35	-0.46	-0.19	-1.65

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
118_sigma_genes	118	115	AKR7L;CTD-3088G3.8;PKD1L2
old_genes_UKB_lifespan	104	103	PRAG1