Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
118_sigma_genes Exclusive	Reactome_pos_beta	1.35e-01	8.33e-04	3.56e-01	4.05e-03
Reactome_pos_beta Exclusive	118_sigma_genes	3.11e-01	1.91e-02	1.20e-01	1.19e-01
118_sigma_genes Exclusive	Reactome_pos_beta Exclusive	1.74e-01	2.83e-03	5.02e-01	6.96e-03
Reactome_pos_beta Exclusive	118_sigma_genes Exclusive	5.47e-01	4.40e-02	1.02e-01	1.09e-01
118_sigma_genes Exclusive	Overlap	6.21e-02	8.90e-02	1.52e-01	8.08e-02
Reactome_pos_beta Exclusive	Overlap	5.42e-03	4.43e-03	6.50e-03	1.03e-02
Overlap	Exclusives	4.35e-08	3.46e-07	3.86e-06	2.08e-04



Evaluating how well 118_sigma_genes genes are linked to Reactome_pos_beta genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
118_sigma_genes Exclusive	Reactome_pos_beta	0.65	1.16	3.56	1.33	3.74
Reactome_pos_beta Exclusive	118_sigma_genes	0.50	1.50	2.75	1.83	-0.07
118_sigma_genes Exclusive	Reactome_pos_beta Exclusive	0.64	0.91	3.35	1.12	2.94
Reactome_pos_beta Exclusive	118_sigma_genes Exclusive	0.49	1.72	2.59	1.18	-0.21
118_sigma_genes Exclusive	Overlap	0.83	1.80	1.89	1.70	1.77
Reactome_pos_beta Exclusive	Overlap	0.96	2.63	2.86	2.64	2.30
Overlap	Exclusives	0.56	2.76	6.67	2.22	2.55

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
118_sigma_genes Exclusive	Reactome_pos_beta	0.00	0.25	1.55	0.03	0.31
Reactome_pos_beta Exclusive	118_sigma_genes	0.01	1.44	2.32	1.09	0.88
118_sigma_genes Exclusive	Reactome_pos_beta Exclusive	0.00	0.09	1.56	-0.04	1.53
Reactome_pos_beta Exclusive	118_sigma_genes Exclusive	0.01	1.11	1.74	0.44	0.20
118_sigma_genes Exclusive	Overlap	0.00	0.23	1.58	0.02	0.12
Reactome_pos_beta Exclusive	Overlap	0.00	0.04	1.37	1.27	4.24
Overlap	Exclusives	0.01	2.81	6.59	1.03	4.03

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
118_sigma_genes Exclusive	116	113	CTD-3088G3.8;AKR7L;PKD1L2
Reactome_pos_beta Exclusive	41	41	
Overlap	2	2