Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
118_sigma_genes Exclusive	66_young_reactome	1.37e-04	1.56e-09	1.78e-02	7.82e-08
66_young_reactome Exclusive	118_sigma_genes	5.26e-03	2.48e-03	9.85e-03	1.01e-02
118_sigma_genes Exclusive	66_young_reactome Exclusive	9.72e-05	6.09e-09	4.68e-03	1.19e-07
66_young_reactome Exclusive	118_sigma_genes Exclusive	2.84e-02	2.52e-03	8.68e-03	1.94e-02
118_sigma_genes Exclusive	Overlap	2.64e-01	1.41e-01	3.37e-01	1.58e-01
66_young_reactome Exclusive	Overlap	6.83e-02	7.98e-02	6.83e-02	8.70e-02
Overlap	Exclusives	3.37e-03	1.04e-02	1.06e-02	2.51e-02



Evaluating how well 118_sigma_genes genes are linked to 66_young_reactome genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
118_sigma_genes Exclusive	66_young_reactome	0.70	2.40	6.62	2.15	5.82
66_young_reactome Exclusive	118_sigma_genes	0.54	4.85	3.67	3.00	1.47
118_sigma_genes Exclusive	66_young_reactome Exclusive	0.70	1.95	6.18	2.27	5.17
66_young_reactome Exclusive	118_sigma_genes Exclusive	0.53	3.54	3.31	2.80	1.51
118_sigma_genes Exclusive	Overlap	0.69	1.37	1.92	1.76	1.63
66_young_reactome Exclusive	Overlap	0.73	2.59	1.90	2.09	2.18
Overlap	Exclusives	0.52	1.68	2.99	1.96	0.87

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
118_sigma_genes Exclusive	66_young_reactome	0.01	1.46	4.65	0.85	5.58
66_young_reactome Exclusive	118_sigma_genes	0.01	7.37	4.04	4.14	3.81
118_sigma_genes Exclusive	66_young_reactome Exclusive	0.01	1.27	2.75	1.09	7.14
66_young_reactome Exclusive	118_sigma_genes Exclusive	0.01	2.29	3.12	1.31	1.04
118_sigma_genes Exclusive	Overlap	0.00	0.53	0.44	0.22	0.87
66_young_reactome Exclusive	Overlap	0.00	9.07	2.82	8.08	4.89
Overlap	Exclusives	0.01	1.83	8.15	3.10	6.26

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
118_sigma_genes Exclusive	112	109	PKD1L2;AKR7L;CTD-3088G3.8
66_young_reactome Exclusive	60	59	MUC19
Overlap	6	6