Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
210_Reactome_Sigma	Aging_GS	6.95e-03	1.98e-02	1.75e-14	4.15e-34
Aging_GS	210_Reactome_Sigma	1.83e-03	4.88e-01	1.04e-06	2.17e-03



Evaluating how well 210_Reactome_Sigma genes are linked to Aging_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
210_Reactome_Sigma	Aging_GS	0.71	0.48	2.51	-0.98	13.33
Aging_GS	210_Reactome_Sigma	0.43	0.04	-1.45	-0.58	-4.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
210_Reactome_Sigma	Aging_GS	0.03	-0.63	0.58	-1.60	11.75
Aging_GS	210_Reactome_Sigma	0.01	1.15	-0.34	-0.30	-1.62

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
210_Reactome_Sigma	210	206	CTD-3088G3.8;PKD1L2;MUC19;AKR7L
Aging_GS	307	306	TERC