Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_78 Exclusive TIER1_GS 4.83e-01 2.16e-01 2.42e-01 5.30e-03 TIER1_GS Exclusive Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_78 3.90e-01 3.56e-01 2.59e-01 1.42e-01 Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_78 Exclusive TIER1_GS Exclusive 2.98e-01 2.54e-01 3.60e-01 3.40e-02 TIER1_GS Exclusive Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_78 Exclusive 8.82e-01 5.19e-01 4.67e-01 2.37e-01 Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_78 Exclusive Overlap 7.22e-01 5.84e-01 5.66e-01 1.98e-01 TIER1_GS Exclusive Overlap 4.36e-07 4.36e-07 4.36e-07 4.36e-07 Overlap Exclusives 1.66e-06 2.27e-06 4.55e-13 1.01e-06 Evaluating how well Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_78 genes are linked to TIER1_GS genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_78 Exclusive TIER1_GS 0.65 0.89 1.63 0.99 2.57 TIER1_GS Exclusive Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_78 0.57 1.32 1.60 1.50 1.83 Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_78 Exclusive TIER1_GS Exclusive 0.63 1.10 1.41 0.76 1.93 TIER1_GS Exclusive Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_78 Exclusive 0.55 1.32 0.95 1.03 1.41 Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_78 Exclusive Overlap 0.81 1.28 1.50 1.25 1.75 TIER1_GS Exclusive Overlap 1.00 3.05 2.71 3.07 3.03 Overlap Exclusives 0.65 3.83 4.96 3.12 5.34 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_78 Exclusive TIER1_GS 0.00 0.96 0.99 0.65 1.50 TIER1_GS Exclusive Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_78 0.01 2.92 11.69 9.01 2.56 Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_78 Exclusive TIER1_GS Exclusive 0.00 0.35 0.27 0.10 1.08 TIER1_GS Exclusive Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_78 Exclusive 0.00 0.56 0.93 0.52 0.68 Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_78 Exclusive Overlap 0.00 6.88 9.24 3.77 1.82 TIER1_GS Exclusive Overlap 0.10 191.69 108.35 611.18 698.11 Overlap Exclusives 0.08 82.82 129.93 41.51 113.99 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_78 Exclusive 75 71 RFPL2;AC099811.2;AC093155.3;IQCJ-SCHIP1 TIER1_GS Exclusive 28 27 MS4A Overlap 3 3