Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_fdr_02 Exclusive	TIER1_GS	1.50e-10	1.12e-09	1.19e-10	6.44e-11
TIER1_GS Exclusive	Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_fdr_02	1.79e-01	2.49e-01	1.14e-01	2.45e-01
Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_fdr_02 Exclusive	TIER1_GS Exclusive	6.24e-09	1.57e-08	1.70e-08	2.86e-09
TIER1_GS Exclusive	Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_fdr_02 Exclusive	4.65e-01	4.80e-01	2.93e-01	3.41e-01
Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_fdr_02 Exclusive	Overlap	2.96e-04	7.71e-02	4.97e-04	2.44e-04
TIER1_GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	7.30e-05	7.71e-06	1.44e-17	1.48e-06



Evaluating how well Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_fdr_02 genes are linked to TIER1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_fdr_02 Exclusive	TIER1_GS	0.86	5.57	6.87	4.52	7.18
TIER1_GS Exclusive	Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_fdr_02	0.55	1.85	1.68	1.55	2.14
Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_fdr_02 Exclusive	TIER1_GS Exclusive	0.85	5.59	6.97	3.92	6.63
TIER1_GS Exclusive	Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_fdr_02 Exclusive	0.54	1.40	1.40	1.00	1.78
Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_fdr_02 Exclusive	Overlap	0.99	3.15	2.96	2.49	2.79
TIER1_GS Exclusive	Overlap	1.00	3.00	2.96	3.01	3.11
Overlap	Exclusives	0.63	3.67	5.87	3.50	4.97

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_fdr_02 Exclusive	TIER1_GS	0.02	46.12	52.49	27.70	5.71
TIER1_GS Exclusive	Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_fdr_02	0.03	25.10	46.99	39.57	40.53
Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_fdr_02 Exclusive	TIER1_GS Exclusive	0.02	48.24	45.58	25.49	3.75
TIER1_GS Exclusive	Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_fdr_02 Exclusive	0.02	29.82	41.84	23.65	32.43
Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_fdr_02 Exclusive	Overlap	0.01	26.76	22.20	15.63	1.92
TIER1_GS Exclusive	Overlap	0.10	222.33	126.28	169.56	423.31
Overlap	Exclusives	0.09	74.15	148.87	90.73	127.44

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
Sigma_EA_AD_APOE34_HC_APOE3_agefiltered_excluding_WCAP_fdr_02 Exclusive	120	116	AC099811.2;IQCJ-SCHIP1;RFPL2;AC093155.3
TIER1_GS Exclusive	28	27	MS4A
Overlap	3	3