Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
R2_AFR_35 Exclusive	31_GS	6.30e-01	6.64e-01	1.91e-01	1.25e-02
31_GS Exclusive	R2_AFR_35	2.69e-01	2.51e-01	5.05e-02	7.91e-03
R2_AFR_35 Exclusive	31_GS Exclusive	6.71e-01	7.87e-01	2.48e-01	3.72e-02
31_GS Exclusive	R2_AFR_35 Exclusive	2.37e-01	2.70e-01	9.12e-02	1.03e-02
R2_AFR_35 Exclusive	Overlap	8.46e-01	7.89e-01	4.76e-01	1.45e-01
31_GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	1.25e-05	2.11e-05	3.63e-21	1.75e-06



Evaluating how well R2_AFR_35 genes are linked to 31_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
R2_AFR_35 Exclusive	31_GS	0.65	0.65	1.26	1.16	2.96
31_GS Exclusive	R2_AFR_35	0.59	1.70	0.83	1.40	2.85
R2_AFR_35 Exclusive	31_GS Exclusive	0.64	0.76	1.21	0.81	2.68
31_GS Exclusive	R2_AFR_35 Exclusive	0.57	1.06	0.77	1.37	2.65
R2_AFR_35 Exclusive	Overlap	0.78	0.20	0.34	0.63	1.87
31_GS Exclusive	Overlap	1.00	2.75	2.65	2.88	3.24
Overlap	Exclusives	0.65	6.64	4.46	3.39	5.09

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
R2_AFR_35 Exclusive	31_GS	0.00	0.51	0.15	1.58	1.42
31_GS Exclusive	R2_AFR_35	0.01	6.11	5.96	7.18	7.79
R2_AFR_35 Exclusive	31_GS Exclusive	0.00	0.34	-0.16	0.28	1.50
31_GS Exclusive	R2_AFR_35 Exclusive	0.01	0.97	0.67	1.28	1.64
R2_AFR_35 Exclusive	Overlap	0.00	2.74	3.22	5.25	6.89
31_GS Exclusive	Overlap	0.10	41.52	551.40	214.79	132.28
Overlap	Exclusives	0.08	165.25	110.76	35.95	103.56

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
R2_AFR_35 Exclusive	93	93	
31_GS Exclusive	27	26	MS4A
Overlap	4	3