Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) 91 Braak genes Exclusive GWAS_Loci 1.46e-01 1.60e-01 2.29e-01 3.96e-04 GWAS_Loci Exclusive 91 Braak genes 4.10e-01 7.06e-01 1.98e-01 6.69e-01 91 Braak genes Exclusive GWAS_Loci Exclusive 1.77e-01 2.97e-01 2.25e-01 4.88e-04 GWAS_Loci Exclusive 91 Braak genes Exclusive 5.06e-01 8.37e-01 2.68e-01 8.80e-01 91 Braak genes Exclusive Overlap 6.61e-01 5.17e-01 8.17e-01 2.52e-01 GWAS_Loci Exclusive Overlap 9.85e-05 9.85e-05 9.85e-05 9.85e-05 Overlap Exclusives 6.53e-06 1.45e-05 3.22e-22 1.39e-05 Evaluating how well 91 Braak genes genes are linked to GWAS_Loci genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 91 Braak genes Exclusive GWAS_Loci 0.59 1.10 1.15 0.75 3.11 GWAS_Loci Exclusive 91 Braak genes 0.52 0.52 0.35 0.44 0.53 91 Braak genes Exclusive GWAS_Loci Exclusive 0.59 1.08 0.78 0.75 3.63 GWAS_Loci Exclusive 91 Braak genes Exclusive 0.51 0.42 0.11 0.16 0.17 91 Braak genes Exclusive Overlap 0.83 1.20 1.34 0.88 1.48 GWAS_Loci Exclusive Overlap 1.00 2.42 2.15 2.15 2.61 Overlap Exclusives 0.62 4.46 4.52 2.25 5.87 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 91 Braak genes Exclusive GWAS_Loci 0.01 1.16 0.96 0.60 1.22 GWAS_Loci Exclusive 91 Braak genes 0.01 1.35 7.63 9.97 3.02 91 Braak genes Exclusive GWAS_Loci Exclusive 0.01 0.74 0.33 0.49 0.99 GWAS_Loci Exclusive 91 Braak genes Exclusive 0.01 1.67 1.50 1.58 1.06 91 Braak genes Exclusive Overlap 0.00 1.15 7.27 0.50 0.43 GWAS_Loci Exclusive Overlap 0.10 128.77 510.64 194.23 673.71 Overlap Exclusives 0.05 43.21 48.83 23.59 39.67 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes 91 Braak genes Exclusive 88 88 GWAS_Loci Exclusive 108 103 PCDH11Y;MIR302F;D21S2088E;LINC00158;SLC8A1-AS1 Overlap 2 2