Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
98_braak_exp2 Exclusive	tier1_GS	4.50e-01	4.34e-01	2.32e-01	6.32e-01
tier1_GS Exclusive	98_braak_exp2	2.74e-01	2.59e-01	8.59e-02	1.82e-01
98_braak_exp2 Exclusive	tier1_GS Exclusive	3.73e-01	3.68e-01	3.08e-01	7.57e-01
tier1_GS Exclusive	98_braak_exp2 Exclusive	2.45e-01	2.45e-01	1.05e-01	3.07e-01
98_braak_exp2 Exclusive	Overlap	5.94e-02	1.98e-02	1.78e-01	7.92e-02
tier1_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	8.38e-04	2.28e-04	3.59e-36	1.95e-04



Evaluating how well 98_braak_exp2 genes are linked to tier1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
98_braak_exp2 Exclusive	tier1_GS	0.54	-0.57	-1.19	-0.90	0.78
tier1_GS Exclusive	98_braak_exp2	0.52	0.60	0.70	1.21	0.64
98_braak_exp2 Exclusive	tier1_GS Exclusive	0.53	-0.58	-1.16	-0.74	0.55
tier1_GS Exclusive	98_braak_exp2 Exclusive	0.51	0.55	0.76	0.70	0.42
98_braak_exp2 Exclusive	Overlap	0.98	1.49	544288305791531.00	1.03	1.80
tier1_GS Exclusive	Overlap	1.00	1.21	inf	1.61	1.74
Overlap	Exclusives	0.60	inf	4.06	2.22	3.85

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
98_braak_exp2 Exclusive	tier1_GS	0.00	-0.27	-0.67	-0.16	0.30
tier1_GS Exclusive	98_braak_exp2	0.01	-0.11	0.15	0.44	0.21
98_braak_exp2 Exclusive	tier1_GS Exclusive	0.00	-0.29	-0.97	-0.42	-0.11
tier1_GS Exclusive	98_braak_exp2 Exclusive	0.00	-0.38	-0.21	-0.42	-0.33
98_braak_exp2 Exclusive	Overlap	0.00	3.00	10236064735444876.00	1.20	2.72
tier1_GS Exclusive	Overlap	0.02	9.94	151272923003761312.00	47.35	15.13
Overlap	Exclusives	0.03	20038848289605028.00	25.78	17.86	29.60

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
98_braak_exp2 Exclusive	97	97	
tier1_GS Exclusive	30	29	MS4A
Overlap	1	1