Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
98_braak_exp2	tier2_GS	3.11e-01	7.71e-01	5.56e-01	1.19e-01
tier2_GS	98_braak_exp2	2.91e-01	7.24e-01	1.15e-03	5.21e-01



Evaluating how well 98_braak_exp2 genes are linked to tier2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
98_braak_exp2	tier2_GS	0.57	-1.66	-0.67	-0.80	1.69
tier2_GS	98_braak_exp2	0.49	-0.64	-0.58	-0.25	-0.17

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
98_braak_exp2	tier2_GS	0.00	-0.75	-0.18	-0.37	1.29
tier2_GS	98_braak_exp2	0.01	-0.56	-0.81	-0.36	-0.32

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
98_braak_exp2	98	98	
tier2_GS	46	43	TNSF13;IGH;TNSF12