Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
98_braak_exp2 Exclusive	GWAS_GS	8.35e-01	9.76e-01	8.52e-01	4.04e-02
GWAS_GS Exclusive	98_braak_exp2	3.10e-01	7.88e-01	4.83e-01	4.96e-01
98_braak_exp2 Exclusive	GWAS_GS Exclusive	6.28e-01	8.93e-01	8.40e-01	4.56e-02
GWAS_GS Exclusive	98_braak_exp2 Exclusive	3.09e-01	7.26e-01	6.54e-01	4.60e-01
98_braak_exp2 Exclusive	Overlap	7.92e-02	1.98e-02	7.92e-02	5.94e-02
GWAS_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	1.34e-04	4.42e-05	7.03e-57	8.81e-07



Evaluating how well 98_braak_exp2 genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
98_braak_exp2 Exclusive	GWAS_GS	0.57	0.01	-0.22	-0.03	2.35
GWAS_GS Exclusive	98_braak_exp2	0.49	-0.15	-0.13	-0.12	-0.29
98_braak_exp2 Exclusive	GWAS_GS Exclusive	0.56	0.25	-0.40	0.02	2.17
GWAS_GS Exclusive	98_braak_exp2 Exclusive	0.49	-0.12	-0.23	-0.28	-0.41
98_braak_exp2 Exclusive	Overlap	0.98	1.39	544288305791531.00	1.19	1.63
GWAS_GS Exclusive	Overlap	1.00	1.22	98784710366980.00	1.35	1.52
Overlap	Exclusives	0.62	393496185650905.00	4.91	2.43	5.60

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
98_braak_exp2 Exclusive	GWAS_GS	0.01	-0.03	-0.22	-0.05	1.39
GWAS_GS Exclusive	98_braak_exp2	0.01	1.59	1.55	0.49	1.19
98_braak_exp2 Exclusive	GWAS_GS Exclusive	0.01	-0.03	-0.54	-0.08	0.88
GWAS_GS Exclusive	98_braak_exp2 Exclusive	0.01	0.23	0.29	-0.19	-0.19
98_braak_exp2 Exclusive	Overlap	0.00	2.49	10236064735444876.00	2.80	2.15
GWAS_GS Exclusive	Overlap	0.04	29.43	inf	60.49	135.86
Overlap	Exclusives	0.03	inf	25.24	12.40	23.15

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
98_braak_exp2 Exclusive	97	97	
GWAS_GS Exclusive	109	104	MIR302F;LINC00158;D21S2088E;SLC8A1-AS1;PCDH11Y
Overlap	1	1