Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
80_Braak_exp3 Exclusive	Tier_gs	3.15e-08	8.45e-09	6.32e-08	1.97e-09
Tier_gs Exclusive	80_Braak_exp3	2.04e-01	1.32e-01	1.13e-01	7.59e-02
80_Braak_exp3 Exclusive	Tier_gs Exclusive	1.99e-07	2.39e-08	9.44e-08	1.22e-08
Tier_gs Exclusive	80_Braak_exp3 Exclusive	3.09e-01	1.82e-01	1.57e-01	1.15e-01
80_Braak_exp3 Exclusive	Overlap	2.72e-02	5.17e-01	2.28e-02	2.76e-03
Tier_gs Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	2.96e-04
Overlap	Exclusives	3.00e-05	2.45e-07	1.76e-25	2.00e-07



Evaluating how well 80_Braak_exp3 genes are linked to Tier_gs genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
80_Braak_exp3 Exclusive	Tier_gs	0.82	4.01	6.40	3.40	5.50
Tier_gs Exclusive	80_Braak_exp3	0.58	2.98	2.62	2.18	2.59
80_Braak_exp3 Exclusive	Tier_gs Exclusive	0.81	3.39	6.91	3.72	5.88
Tier_gs Exclusive	80_Braak_exp3 Exclusive	0.57	2.55	2.27	2.09	2.21
80_Braak_exp3 Exclusive	Overlap	0.98	2.44	2.32	2.07	2.14
Tier_gs Exclusive	Overlap	1.00	3.46	1.93	2.81	2.42
Overlap	Exclusives	0.67	4.38	7.46	2.98	5.89

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
80_Braak_exp3 Exclusive	Tier_gs	0.02	24.96	37.37	19.41	24.26
Tier_gs Exclusive	80_Braak_exp3	0.02	28.56	48.65	32.71	26.61
80_Braak_exp3 Exclusive	Tier_gs Exclusive	0.01	21.63	30.02	19.65	17.09
Tier_gs Exclusive	80_Braak_exp3 Exclusive	0.02	10.75	33.45	7.35	25.14
80_Braak_exp3 Exclusive	Overlap	0.00	7.55	39.37	6.13	11.43
Tier_gs Exclusive	Overlap	0.07	215.16	203.27	439.68	5.20
Overlap	Exclusives	0.09	35.24	156.12	46.97	123.07

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
80_Braak_exp3 Exclusive	78	77	AC091959.3
Tier_gs Exclusive	29	28	MS4A
Overlap	2	2