Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
80_Braak_exp3	Tier2_GS	9.34e-01	5.24e-01	3.28e-01	2.55e-02
Tier2_GS	80_Braak_exp3	8.04e-01	9.94e-01	8.56e-02	5.42e-01



Evaluating how well 80_Braak_exp3 genes are linked to Tier2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
80_Braak_exp3	Tier2_GS	0.63	0.21	1.29	1.21	3.13
Tier2_GS	80_Braak_exp3	0.53	0.59	0.21	0.46	0.98

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
80_Braak_exp3	Tier2_GS	0.01	2.38	4.00	4.34	3.49
Tier2_GS	80_Braak_exp3	0.01	3.62	0.28	0.89	1.02

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
80_Braak_exp3	80	79	AC091959.3
Tier2_GS	46	43	TNSF13;IGH;TNSF12