Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
80_Braak_exp3 Exclusive	GWAS_loci	1.16e-07	3.20e-07	4.18e-07	2.91e-11
GWAS_loci Exclusive	80_Braak_exp3	8.13e-02	9.42e-02	4.71e-03	6.19e-02
80_Braak_exp3 Exclusive	GWAS_loci Exclusive	6.31e-07	5.90e-07	2.57e-07	4.55e-10
GWAS_loci Exclusive	80_Braak_exp3 Exclusive	1.70e-01	1.00e-01	1.64e-02	1.15e-01
80_Braak_exp3 Exclusive	Overlap	1.04e-01	8.22e-02	1.27e-01	9.38e-02
GWAS_loci Exclusive	Overlap	2.94e-02	7.71e-02	1.27e-02	1.96e-03
Overlap	Exclusives	1.32e-05	9.07e-08	2.72e-26	1.19e-11



Evaluating how well 80_Braak_exp3 genes are linked to GWAS_loci genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
80_Braak_exp3 Exclusive	GWAS_loci	0.70	5.09	6.71	4.14	6.85
GWAS_loci Exclusive	80_Braak_exp3	0.59	3.58	3.20	2.68	2.78
80_Braak_exp3 Exclusive	GWAS_loci Exclusive	0.70	5.17	5.72	4.66	6.93
GWAS_loci Exclusive	80_Braak_exp3 Exclusive	0.57	2.88	2.54	2.46	2.37
80_Braak_exp3 Exclusive	Overlap	0.88	2.50	1.81	2.08	2.09
GWAS_loci Exclusive	Overlap	0.96	3.52	2.13	2.46	2.72
Overlap	Exclusives	0.66	5.23	7.07	3.44	8.70

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
80_Braak_exp3 Exclusive	GWAS_loci	0.02	18.07	26.60	11.91	11.80
GWAS_loci Exclusive	80_Braak_exp3	0.03	48.29	55.58	52.54	43.50
80_Braak_exp3 Exclusive	GWAS_loci Exclusive	0.02	18.56	22.89	16.74	10.29
GWAS_loci Exclusive	80_Braak_exp3 Exclusive	0.02	39.10	37.77	34.45	28.15
80_Braak_exp3 Exclusive	Overlap	0.00	13.34	7.94	8.13	11.94
GWAS_loci Exclusive	Overlap	0.07	174.45	323.75	121.05	213.78
Overlap	Exclusives	0.05	30.40	54.71	28.06	45.25

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
80_Braak_exp3 Exclusive	77	76	AC091959.3
GWAS_loci Exclusive	107	102	D21S2088E;SLC8A1-AS1;MIR302F;PCDH11Y;LINC00158
Overlap	3	3