Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
80_Braak_exp2	Ismael	6.08e-02	8.93e-03	3.99e-02	4.21e-03
Ismael	80_Braak_exp2	3.49e-01	5.73e-02	4.43e-06	1.38e-02



Evaluating how well 80_Braak_exp2 genes are linked to Ismael genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
80_Braak_exp2	Ismael	0.80	1.72	3.32	1.80	4.01
Ismael	80_Braak_exp2	0.58	3.73	2.84	2.61	2.50

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
80_Braak_exp2	Ismael	0.00	4.08	3.76	4.47	6.35
Ismael	80_Braak_exp2	0.01	3.87	3.20	2.46	2.99

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
80_Braak_exp2	80	79	AC091959.3
Ismael	14	14