Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
GeneGroup1	Ismael_GS	9.23e-01	9.03e-01	9.06e-01	1.21e-01
Ismael_GS	GeneGroup1	2.09e-02	6.09e-01	2.25e-06	7.06e-01



Evaluating how well GeneGroup1 genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1	Ismael_GS	0.65	-0.06	-0.06	0.08	2.13
Ismael_GS	GeneGroup1	0.52	1.39	0.89	1.17	0.65

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
GeneGroup1	Ismael_GS	0.00	0.48	0.63	0.44	0.47
Ismael_GS	GeneGroup1	0.01	0.29	-0.08	0.22	0.04

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
GeneGroup1	98	98	
Ismael_GS	14	14