Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
60_exp4 Exclusive	Tier1_GS	2.81e-01	1.66e-01	3.39e-01	5.10e-02
Tier1_GS Exclusive	60_exp4	2.99e-01	5.68e-01	2.68e-01	4.50e-01
60_exp4 Exclusive	Tier1_GS Exclusive	3.67e-01	1.11e-01	2.50e-01	4.68e-02
Tier1_GS Exclusive	60_exp4 Exclusive	3.10e-01	7.21e-01	6.15e-01	4.49e-01
60_exp4 Exclusive	Overlap	7.08e-01	4.03e-01	8.04e-01	1.41e-01
Tier1_GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	1.82e-05	1.57e-05	1.04e-11	1.19e-05



Evaluating how well 60_exp4 genes are linked to Tier1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
60_exp4 Exclusive	Tier1_GS	0.63	0.75	1.36	0.65	2.39
Tier1_GS Exclusive	60_exp4	0.54	1.10	1.14	1.08	1.03
60_exp4 Exclusive	Tier1_GS Exclusive	0.62	0.50	1.58	0.73	2.06
Tier1_GS Exclusive	60_exp4 Exclusive	0.53	0.84	0.42	0.96	0.95
60_exp4 Exclusive	Overlap	0.76	0.64	0.07	0.46	1.36
Tier1_GS Exclusive	Overlap	1.00	2.38	2.12	2.36	2.75
Overlap	Exclusives	0.65	4.89	5.44	2.22	5.28

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
60_exp4 Exclusive	Tier1_GS	0.00	0.28	0.58	0.23	0.33
Tier1_GS Exclusive	60_exp4	0.01	3.08	1.17	1.12	3.85
60_exp4 Exclusive	Tier1_GS Exclusive	0.00	0.10	0.51	0.06	0.48
Tier1_GS Exclusive	60_exp4 Exclusive	0.00	0.30	-0.09	0.47	0.04
60_exp4 Exclusive	Overlap	0.00	-0.21	-0.93	-0.40	-0.08
Tier1_GS Exclusive	Overlap	0.05	112.07	91.67	186.21	362.58
Overlap	Exclusives	0.04	42.70	77.57	21.54	22.38

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
60_exp4 Exclusive	58	58	
Tier1_GS Exclusive	29	28	MS4A
Overlap	2	2