Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
60_exp4	Tier2	2.79e-02	1.17e-03	2.53e-03	1.62e-05
Tier2	60_exp4	1.95e-01	2.32e-01	9.25e-03	8.66e-02



Evaluating how well 60_exp4 genes are linked to Tier2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
60_exp4	Tier2	0.72	2.56	4.22	3.11	5.27
Tier2	60_exp4	0.58	3.13	1.95	2.45	2.24

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
60_exp4	Tier2	0.01	4.59	3.55	3.66	8.09
Tier2	60_exp4	0.02	9.83	26.59	26.94	40.46

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
60_exp4	60	60	
Tier2	46	43	IGH;TNSF13;TNSF12