Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
60_exp2 Exclusive	Gwas_GS	4.70e-01	3.09e-01	4.73e-01	1.28e-03
Gwas_GS Exclusive	60_exp2	3.41e-01	6.32e-01	1.47e-01	4.59e-01
60_exp2 Exclusive	Gwas_GS Exclusive	3.45e-01	2.92e-01	5.01e-01	6.52e-04
Gwas_GS Exclusive	60_exp2 Exclusive	6.68e-01	6.11e-01	2.70e-01	8.12e-01
60_exp2 Exclusive	Overlap	7.23e-01	4.03e-01	7.79e-01	2.24e-01
Gwas_GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	1.13e-05	1.62e-06	3.41e-20	3.05e-08



Evaluating how well 60_exp2 genes are linked to Gwas_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
60_exp2 Exclusive	Gwas_GS	0.60	0.81	1.54	1.22	3.58
Gwas_GS Exclusive	60_exp2	0.54	1.55	1.27	1.11	1.15
60_exp2 Exclusive	Gwas_GS Exclusive	0.59	1.26	1.50	0.85	3.82
Gwas_GS Exclusive	60_exp2 Exclusive	0.53	1.17	1.24	0.97	0.58
60_exp2 Exclusive	Overlap	0.76	0.55	-0.05	0.65	1.30
Gwas_GS Exclusive	Overlap	1.00	2.80	2.14	2.57	2.62
Overlap	Exclusives	0.65	5.86	6.73	2.60	7.07

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
60_exp2 Exclusive	Gwas_GS	0.01	0.19	1.25	0.69	1.49
Gwas_GS Exclusive	60_exp2	0.01	5.49	7.84	5.96	9.98
60_exp2 Exclusive	Gwas_GS Exclusive	0.01	0.73	1.27	0.42	0.93
Gwas_GS Exclusive	60_exp2 Exclusive	0.00	0.74	1.63	0.55	0.56
60_exp2 Exclusive	Overlap	0.00	-0.22	-0.95	-0.33	-0.08
Gwas_GS Exclusive	Overlap	0.10	104.16	247.32	270.65	118.51
Overlap	Exclusives	0.05	41.51	65.16	25.77	40.51

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
60_exp2 Exclusive	58	58	
Gwas_GS Exclusive	108	103	LINC00158;SLC8A1-AS1;D21S2088E;PCDH11Y;MIR302F
Overlap	2	2