Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
60_exp4	Ismael_GS	2.78e-04	4.83e-05	1.19e-04	8.38e-06
Ismael_GS	60_exp4	6.04e-01	8.55e-01	3.25e-03	6.93e-01



Evaluating how well 60_exp4 genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
60_exp4	Ismael_GS	0.86	2.01	4.36	2.64	5.00
Ismael_GS	60_exp4	0.53	1.67	0.61	0.89	0.95

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
60_exp4	Ismael_GS	0.01	6.34	17.90	5.14	6.40
Ismael_GS	60_exp4	0.01	9.04	3.60	1.38	1.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
60_exp4	60	60	
Ismael_GS	14	14