Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
99_Exp5 Exclusive	Tier1_GS	1.09e-01	2.21e-01	1.58e-01	7.73e-04
Tier1_GS Exclusive	99_Exp5	5.22e-01	5.56e-01	5.35e-01	7.15e-01
99_Exp5 Exclusive	Tier1_GS Exclusive	2.01e-01	1.23e-01	1.60e-01	8.34e-03
Tier1_GS Exclusive	99_Exp5 Exclusive	3.55e-01	7.80e-01	8.69e-01	9.11e-01
99_Exp5 Exclusive	Overlap	1.81e-01	4.58e-01	1.98e-01	2.60e-02
Tier1_GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	1.59e-04	4.98e-05	2.36e-18	2.91e-06



Evaluating how well 99_Exp5 genes are linked to Tier1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
99_Exp5 Exclusive	Tier1_GS	0.67	1.43	1.71	1.04	3.55
Tier1_GS Exclusive	99_Exp5	0.53	0.78	0.83	0.79	1.05
99_Exp5 Exclusive	Tier1_GS Exclusive	0.65	1.25	1.80	1.24	2.50
Tier1_GS Exclusive	99_Exp5 Exclusive	0.51	0.07	0.56	0.39	0.63
99_Exp5 Exclusive	Overlap	0.89	2.03	1.67	1.92	2.28
Tier1_GS Exclusive	Overlap	1.00	2.80	2.78	3.13	3.24
Overlap	Exclusives	0.64	4.28	6.65	3.46	5.75

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
99_Exp5 Exclusive	Tier1_GS	0.00	0.20	2.53	1.06	1.24
Tier1_GS Exclusive	99_Exp5	0.01	2.50	7.51	5.76	7.46
99_Exp5 Exclusive	Tier1_GS Exclusive	0.00	0.47	2.23	2.41	1.41
Tier1_GS Exclusive	99_Exp5 Exclusive	0.01	-0.15	0.82	0.12	0.71
99_Exp5 Exclusive	Overlap	0.00	3.33	2.09	2.15	1.89
Tier1_GS Exclusive	Overlap	0.06	111.77	114.98	310.56	275.10
Overlap	Exclusives	0.06	57.21	120.35	29.24	55.53

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
99_Exp5 Exclusive	96	96	
Tier1_GS Exclusive	28	27	MS4A
Overlap	3	3