Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
99_exp5 Exclusive	Tier2_GS	6.19e-01	2.54e-01	4.76e-01	8.23e-03
Tier2_GS Exclusive	99_exp5	9.01e-01	5.01e-01	1.94e-02	2.20e-01
99_exp5 Exclusive	Tier2_GS Exclusive	6.09e-01	3.83e-01	5.21e-01	1.44e-02
Tier2_GS Exclusive	99_exp5 Exclusive	8.68e-01	4.87e-01	1.15e-02	2.78e-01
99_exp5 Exclusive	Overlap	6.53e-01	5.35e-01	7.33e-01	2.77e-01
Tier2_GS Exclusive	Overlap	3.96e-02	1.98e-02	9.90e-02	1.19e-01
Overlap	Exclusives	1.84e-02	5.74e-01	2.19e-28	1.00e-01



Evaluating how well 99_exp5 genes are linked to Tier2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
99_exp5 Exclusive	Tier2_GS	0.64	0.86	1.80	1.09	4.03
Tier2_GS Exclusive	99_exp5	0.53	0.58	0.56	0.50	0.95
99_exp5 Exclusive	Tier2_GS Exclusive	0.64	0.88	1.52	1.02	3.03
Tier2_GS Exclusive	99_exp5 Exclusive	0.52	0.39	0.58	0.72	0.98
99_exp5 Exclusive	Overlap	0.87	0.45	-0.11	0.42	1.22
Tier2_GS Exclusive	Overlap	0.94	1.68	2.56	1.14	1.55
Overlap	Exclusives	0.55	0.56	1.52	0.73	2.01

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
99_exp5 Exclusive	Tier2_GS	0.00	0.91	0.88	1.03	4.46
Tier2_GS Exclusive	99_exp5	0.01	5.45	4.26	5.41	3.20
99_exp5 Exclusive	Tier2_GS Exclusive	0.00	0.78	1.10	1.19	1.72
Tier2_GS Exclusive	99_exp5 Exclusive	0.01	5.63	5.04	2.84	2.92
99_exp5 Exclusive	Overlap	0.00	-0.22	-0.58	-0.22	0.03
Tier2_GS Exclusive	Overlap	0.00	2.90	8.65	0.50	0.00
Overlap	Exclusives	0.01	0.32	2.44	0.73	1.31

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
99_exp5 Exclusive	98	98	
Tier2_GS Exclusive	45	42	TNSF13;TNSF12;IGH
Overlap	1	1