Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
99_Exp5 Exclusive	GWAS_GS	1.14e-01	3.22e-01	1.62e-01	4.29e-05
GWAS_GS Exclusive	99_Exp5	1.79e-01	1.48e-01	1.96e-02	1.34e-01
99_Exp5 Exclusive	GWAS_GS Exclusive	7.52e-02	2.54e-01	1.28e-01	3.87e-04
GWAS_GS Exclusive	99_Exp5 Exclusive	4.33e-01	2.11e-01	9.31e-02	2.88e-01
99_Exp5 Exclusive	Overlap	7.06e-01	7.54e-01	7.46e-01	3.48e-02
GWAS_GS Exclusive	Overlap	1.83e-09	1.83e-09	1.83e-09	1.83e-09
Overlap	Exclusives	1.02e-04	6.86e-05	2.75e-39	3.89e-08



Evaluating how well 99_Exp5 genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
99_Exp5 Exclusive	GWAS_GS	0.62	1.69	1.77	1.51	4.91
GWAS_GS Exclusive	99_Exp5	0.56	2.07	2.23	1.98	1.94
99_Exp5 Exclusive	GWAS_GS Exclusive	0.61	1.94	1.66	1.62	3.99
GWAS_GS Exclusive	99_Exp5 Exclusive	0.54	1.48	1.92	1.49	1.45
99_Exp5 Exclusive	Overlap	0.80	0.83	0.02	0.65	1.87
GWAS_GS Exclusive	Overlap	1.00	3.40	3.00	2.97	3.28
Overlap	Exclusives	0.64	4.04	7.04	3.06	6.36

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
99_Exp5 Exclusive	GWAS_GS	0.01	1.85	1.65	1.01	3.20
GWAS_GS Exclusive	99_Exp5	0.01	6.32	15.94	7.33	7.13
99_Exp5 Exclusive	GWAS_GS Exclusive	0.01	1.71	1.52	1.47	2.68
GWAS_GS Exclusive	99_Exp5 Exclusive	0.01	0.63	2.26	0.74	0.80
99_Exp5 Exclusive	Overlap	0.00	0.50	-0.53	0.13	0.19
GWAS_GS Exclusive	Overlap	0.15	307.46	235.63	260.42	649.25
Overlap	Exclusives	0.07	52.00	88.21	44.08	78.83

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
99_Exp5 Exclusive	95	95	
GWAS_GS Exclusive	106	101	SLC8A1-AS1;MIR302F;PCDH11Y;LINC00158;D21S2088E
Overlap	4	4