Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) 99_Exp5 14_Ismael 1.30e-01 8.53e-02 7.85e-02 1.20e-02 14_Ismael 99_Exp5 6.49e-01 8.39e-02 3.47e-05 6.79e-02 Evaluating how well 99_Exp5 genes are linked to 14_Ismael genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 99_Exp5 14_Ismael 0.74 1.21 1.64 1.07 2.99 14_Ismael 99_Exp5 0.55 2.59 2.01 1.95 1.76 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 99_Exp5 14_Ismael 0.00 2.03 0.31 2.16 3.70 14_Ismael 99_Exp5 0.01 1.73 1.78 1.36 1.48 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes 99_Exp5 99 99 14_Ismael 14 14