Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
138_exp6 Exclusive	Tier1_GS	5.68e-01	9.54e-01	4.89e-01	2.79e-01
Tier1_GS Exclusive	138_exp6	7.66e-01	5.05e-01	4.04e-01	8.12e-01
138_exp6 Exclusive	Tier1_GS Exclusive	8.64e-01	9.76e-01	6.45e-01	3.94e-01
Tier1_GS Exclusive	138_exp6 Exclusive	8.45e-01	6.03e-01	6.21e-01	9.87e-01
138_exp6 Exclusive	Overlap	1.70e-01	7.22e-01	1.81e-01	1.23e-01
Tier1_GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	2.90e-03	9.84e-06	1.03e-21	1.91e-05



Evaluating how well 138_exp6 genes are linked to Tier1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
138_exp6 Exclusive	Tier1_GS	0.60	0.31	0.43	0.03	1.88
Tier1_GS Exclusive	138_exp6	0.52	1.36	1.36	1.17	0.87
138_exp6 Exclusive	Tier1_GS Exclusive	0.58	0.08	0.24	-0.06	1.24
Tier1_GS Exclusive	138_exp6 Exclusive	0.51	0.91	1.11	0.89	0.34
138_exp6 Exclusive	Overlap	0.81	1.24	0.77	1.21	2.05
Tier1_GS Exclusive	Overlap	1.00	2.97	2.88	2.96	2.75
Overlap	Exclusives	0.60	3.85	6.64	3.31	5.13

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
138_exp6 Exclusive	Tier1_GS	0.00	0.78	0.26	0.31	1.09
Tier1_GS Exclusive	138_exp6	0.01	1.94	1.87	2.46	3.34
138_exp6 Exclusive	Tier1_GS Exclusive	0.00	0.02	0.18	-0.07	0.03
Tier1_GS Exclusive	138_exp6 Exclusive	0.01	-0.05	0.29	0.24	-0.14
138_exp6 Exclusive	Overlap	0.00	2.04	-0.48	3.61	1.93
Tier1_GS Exclusive	Overlap	0.06	166.26	235.54	222.91	41.39
Overlap	Exclusives	0.05	29.83	55.88	38.64	76.46

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
138_exp6 Exclusive	135	135	
Tier1_GS Exclusive	28	27	MS4A
Overlap	3	3