Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
138_exp6	Tier2_GS	1.02e-01	8.81e-02	6.08e-02	4.28e-04
Tier2_GS	138_exp6	1.87e-01	1.13e-01	2.14e-04	1.87e-01



Evaluating how well 138_exp6 genes are linked to Tier2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
138_exp6	Tier2_GS	0.69	2.52	2.72	2.65	4.67
Tier2_GS	138_exp6	0.55	2.00	2.04	2.08	2.12

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
138_exp6	Tier2_GS	0.01	4.14	5.16	4.73	9.25
Tier2_GS	138_exp6	0.02	11.03	10.46	12.47	13.73

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
138_exp6	138	138	
Tier2_GS	46	43	TNSF13;IGH;TNSF12