Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
138_exp6	Ismael_GS	4.55e-01	5.84e-01	4.20e-01	1.02e-02
Ismael_GS	138_exp6	3.57e-01	6.72e-02	2.40e-09	1.48e-01



Evaluating how well 138_exp6 genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
138_exp6	Ismael_GS	0.74	1.00	1.47	1.08	3.10
Ismael_GS	138_exp6	0.54	3.40	2.74	2.05	1.85

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
138_exp6	Ismael_GS	0.00	0.50	1.30	0.36	1.48
Ismael_GS	138_exp6	0.01	1.78	1.32	0.76	1.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
138_exp6	138	138	
Ismael_GS	14	14