Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
122_exp7 Exclusive	Tier1_GS	2.42e-01	3.77e-01	4.75e-01	3.92e-03
Tier1_GS Exclusive	122_exp7	4.24e-01	6.72e-01	5.27e-01	7.88e-01
122_exp7 Exclusive	Tier1_GS Exclusive	4.26e-01	4.40e-01	5.08e-01	1.08e-02
Tier1_GS Exclusive	122_exp7 Exclusive	3.40e-01	8.91e-01	5.37e-01	9.10e-01
122_exp7 Exclusive	Overlap	8.57e-01	7.89e-01	8.57e-01	2.22e-01
Tier1_GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	1.74e-06
Overlap	Exclusives	9.12e-04	8.37e-05	4.84e-20	1.30e-04



Evaluating how well 122_exp7 genes are linked to Tier1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_exp7 Exclusive	Tier1_GS	0.65	1.09	1.04	0.66	2.79
Tier1_GS Exclusive	122_exp7	0.52	0.41	0.64	0.58	0.80
122_exp7 Exclusive	Tier1_GS Exclusive	0.63	1.07	0.88	0.66	2.40
Tier1_GS Exclusive	122_exp7 Exclusive	0.51	-0.01	0.32	0.16	0.38
122_exp7 Exclusive	Overlap	0.76	0.74	0.11	0.52	1.68
Tier1_GS Exclusive	Overlap	1.00	2.67	2.89	2.90	3.02
Overlap	Exclusives	0.60	4.68	5.21	3.16	4.34

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_exp7 Exclusive	Tier1_GS	0.00	0.73	0.39	0.13	1.10
Tier1_GS Exclusive	122_exp7	0.01	4.17	5.52	4.70	3.11
122_exp7 Exclusive	Tier1_GS Exclusive	0.00	-0.06	0.18	-0.00	0.84
Tier1_GS Exclusive	122_exp7 Exclusive	0.01	-0.31	0.31	-0.10	-0.05
122_exp7 Exclusive	Overlap	0.00	0.77	0.48	0.44	0.60
Tier1_GS Exclusive	Overlap	0.06	121.00	148.64	299.83	56.82
Overlap	Exclusives	0.05	59.01	80.75	39.48	48.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
122_exp7 Exclusive	119	119	
Tier1_GS Exclusive	28	27	MS4A
Overlap	3	3