Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
122_exp7 Exclusive	tier2_GS	7.02e-02	3.19e-02	5.12e-02	7.64e-04
tier2_GS Exclusive	122_exp7	7.43e-01	5.43e-01	8.60e-03	5.62e-01
122_exp7 Exclusive	tier2_GS Exclusive	8.76e-02	5.05e-02	5.64e-02	1.91e-03
tier2_GS Exclusive	122_exp7 Exclusive	7.53e-01	5.24e-01	4.77e-03	6.89e-01
122_exp7 Exclusive	Overlap	5.35e-01	9.90e-01	9.31e-01	1.58e-01
tier2_GS Exclusive	Overlap	1.98e-02	1.98e-02	9.90e-02	5.94e-02
Overlap	Exclusives	3.06e-02	9.34e-01	6.87e-33	4.02e-01



Evaluating how well 122_exp7 genes are linked to tier2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_exp7 Exclusive	tier2_GS	0.65	1.30	2.04	1.66	3.77
tier2_GS Exclusive	122_exp7	0.52	0.88	1.09	0.88	0.82
122_exp7 Exclusive	tier2_GS Exclusive	0.65	1.25	2.05	1.55	3.09
tier2_GS Exclusive	122_exp7 Exclusive	0.52	0.94	0.79	0.75	0.70
122_exp7 Exclusive	Overlap	0.86	0.50	0.14	0.20	1.49
tier2_GS Exclusive	Overlap	0.94	1.85	2.66	1.27	1.48
Overlap	Exclusives	0.52	0.18	0.46	0.20	0.94

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_exp7 Exclusive	tier2_GS	0.00	1.23	1.51	1.15	2.44
tier2_GS Exclusive	122_exp7	0.01	5.86	6.37	2.83	4.74
122_exp7 Exclusive	tier2_GS Exclusive	0.00	1.55	2.04	1.39	2.23
tier2_GS Exclusive	122_exp7 Exclusive	0.01	6.43	5.12	2.07	4.47
122_exp7 Exclusive	Overlap	0.00	-0.14	-0.56	-0.28	-0.05
tier2_GS Exclusive	Overlap	0.00	5.77	9.25	1.10	1.59
Overlap	Exclusives	0.01	0.01	1.44	0.29	0.65

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
122_exp7 Exclusive	121	121	
tier2_GS Exclusive	45	42	IGH;TNSF12;TNSF13
Overlap	1	1