Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
122_exp7 Exclusive	GWAS_GS	1.54e-01	5.50e-01	5.03e-01	2.03e-03
GWAS_GS Exclusive	122_exp7	2.72e-01	6.20e-02	1.19e-02	1.05e-01
122_exp7 Exclusive	GWAS_GS Exclusive	6.04e-02	2.38e-01	1.37e-01	2.34e-03
GWAS_GS Exclusive	122_exp7 Exclusive	5.20e-01	6.02e-02	1.82e-02	1.19e-01
122_exp7 Exclusive	Overlap	6.72e-01	3.74e-01	5.24e-01	2.04e-01
GWAS_GS Exclusive	Overlap	7.20e-04	7.20e-04	7.20e-04	7.55e-04
Overlap	Exclusives	5.74e-04	9.34e-05	5.15e-35	3.27e-06



Evaluating how well 122_exp7 genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_exp7 Exclusive	GWAS_GS	0.61	1.64	1.55	1.33	3.76
GWAS_GS Exclusive	122_exp7	0.55	1.99	1.93	1.74	1.51
122_exp7 Exclusive	GWAS_GS Exclusive	0.61	1.87	1.79	1.42	3.73
GWAS_GS Exclusive	122_exp7 Exclusive	0.53	1.60	1.76	1.50	1.30
122_exp7 Exclusive	Overlap	0.69	0.29	-0.41	0.08	1.34
GWAS_GS Exclusive	Overlap	0.92	3.33	2.80	2.82	3.03
Overlap	Exclusives	0.62	2.94	7.47	3.17	5.73

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
122_exp7 Exclusive	GWAS_GS	0.01	0.77	1.36	0.92	2.32
GWAS_GS Exclusive	122_exp7	0.01	10.31	13.23	6.87	5.31
122_exp7 Exclusive	GWAS_GS Exclusive	0.01	0.69	1.22	1.11	2.96
GWAS_GS Exclusive	122_exp7 Exclusive	0.01	1.42	1.77	0.65	1.19
122_exp7 Exclusive	Overlap	0.00	0.03	-0.74	-0.31	0.00
GWAS_GS Exclusive	Overlap	0.12	235.14	232.48	389.99	23.06
Overlap	Exclusives	0.06	35.54	74.28	41.97	63.96

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
122_exp7 Exclusive	117	117	
GWAS_GS Exclusive	105	100	LINC00158;D21S2088E;MIR302F;SLC8A1-AS1;PCDH11Y
Overlap	5	5