Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
99_exp8 Exclusive	GS_GWAS	1.08e-01	4.76e-01	2.08e-01	2.36e-03
GS_GWAS Exclusive	99_exp8	3.17e-01	4.78e-01	2.02e-01	4.96e-01
99_exp8 Exclusive	GS_GWAS Exclusive	1.91e-01	5.76e-01	2.13e-01	3.81e-03
GS_GWAS Exclusive	99_exp8 Exclusive	5.13e-01	5.84e-01	3.73e-01	6.67e-01
99_exp8 Exclusive	Overlap	4.31e-01	5.74e-01	5.17e-01	8.08e-02
GS_GWAS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	1.56e-04	4.61e-06	6.95e-42	3.93e-08



Evaluating how well 99_exp8 genes are linked to GS_GWAS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
99_exp8 Exclusive	GS_GWAS	0.59	1.18	0.87	0.55	3.05
GS_GWAS Exclusive	99_exp8	0.53	0.37	1.16	0.27	0.77
99_exp8 Exclusive	GS_GWAS Exclusive	0.58	1.04	0.77	0.57	2.98
GS_GWAS Exclusive	99_exp8 Exclusive	0.52	0.25	0.80	0.20	0.71
99_exp8 Exclusive	Overlap	0.87	2.14	0.81	1.31	1.95
GS_GWAS Exclusive	Overlap	1.00	2.20	1.52	2.71	2.20
Overlap	Exclusives	0.65	6.80	6.33	3.40	7.08

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
99_exp8 Exclusive	GS_GWAS	0.01	1.73	1.13	0.80	2.37
GS_GWAS Exclusive	99_exp8	0.01	7.53	12.51	5.95	8.87
99_exp8 Exclusive	GS_GWAS Exclusive	0.01	1.50	1.45	0.58	2.71
GS_GWAS Exclusive	99_exp8 Exclusive	0.01	2.39	4.01	0.87	0.98
99_exp8 Exclusive	Overlap	0.00	2.80	1.30	1.66	0.61
GS_GWAS Exclusive	Overlap	0.10	122.90	394.21	184.91	340.15
Overlap	Exclusives	0.06	26.45	61.40	27.34	53.44

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
99_exp8 Exclusive	97	95	NT5C1B-RDH14;AC091959.3
GS_GWAS Exclusive	108	103	D21S2088E;LINC00158;MIR302F;SLC8A1-AS1;PCDH11Y
Overlap	2	2