Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
99_exp8 Exclusive	Tier1_GS	5.36e-02	2.77e-01	2.16e-01	1.57e-02
Tier1_GS Exclusive	99_exp8	4.91e-01	5.81e-01	6.23e-01	6.79e-01
99_exp8 Exclusive	Tier1_GS Exclusive	5.99e-02	3.40e-01	4.81e-01	3.03e-02
Tier1_GS Exclusive	99_exp8 Exclusive	4.52e-01	6.10e-01	9.75e-01	8.32e-01
99_exp8 Exclusive	Overlap	5.55e-01	6.10e-01	6.10e-01	1.31e-01
Tier1_GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	2.96e-04
Overlap	Exclusives	7.29e-04	1.12e-05	5.25e-28	3.29e-05



Evaluating how well 99_exp8 genes are linked to Tier1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
99_exp8 Exclusive	Tier1_GS	0.63	1.25	1.01	0.42	2.62
Tier1_GS Exclusive	99_exp8	0.52	0.83	1.34	0.76	0.81
99_exp8 Exclusive	Tier1_GS Exclusive	0.61	1.21	0.88	0.28	2.08
Tier1_GS Exclusive	99_exp8 Exclusive	0.51	0.76	1.27	0.20	0.56
99_exp8 Exclusive	Overlap	0.87	1.61	0.66	1.21	1.94
Tier1_GS Exclusive	Overlap	1.00	3.68	1.53	2.58	2.39
Overlap	Exclusives	0.64	6.02	7.52	3.77	5.33

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
99_exp8 Exclusive	Tier1_GS	0.00	1.36	0.89	0.15	0.55
Tier1_GS Exclusive	99_exp8	0.01	1.78	5.97	3.06	1.79
99_exp8 Exclusive	Tier1_GS Exclusive	0.00	1.12	0.70	-0.06	0.76
Tier1_GS Exclusive	99_exp8 Exclusive	0.01	0.14	1.52	-0.09	0.20
99_exp8 Exclusive	Overlap	0.00	2.94	0.73	1.67	1.84
Tier1_GS Exclusive	Overlap	0.07	255.46	112.20	223.25	39.89
Overlap	Exclusives	0.05	37.86	111.70	35.26	41.11

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
99_exp8 Exclusive	97	95	AC091959.3;NT5C1B-RDH14
Tier1_GS Exclusive	29	28	MS4A
Overlap	2	2