Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
99_exp8	GS_TIER2	6.60e-01	6.01e-01	8.61e-01	5.29e-01
GS_TIER2	99_exp8	1.54e-01	3.79e-01	8.66e-04	3.95e-01



Evaluating how well 99_exp8 genes are linked to GS_TIER2 genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
99_exp8	GS_TIER2	0.56	-1.05	-0.54	-0.75	1.42
GS_TIER2	99_exp8	0.52	0.86	0.42	0.46	0.59

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
99_exp8	GS_TIER2	0.00	0.77	1.29	0.48	2.48
GS_TIER2	99_exp8	0.01	1.21	0.06	0.30	0.42

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
99_exp8	99	97	NT5C1B-RDH14;AC091959.3
GS_TIER2	46	43	TNSF12;TNSF13;IGH