Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
99_exp8	ISMAEL_GS	5.88e-01	8.71e-01	7.38e-01	2.07e-01
ISMAEL_GS	99_exp8	2.35e-01	5.86e-01	3.37e-03	3.91e-01



Evaluating how well 99_exp8 genes are linked to ISMAEL_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
99_exp8	ISMAEL_GS	0.65	0.28	0.12	-0.13	1.96
ISMAEL_GS	99_exp8	0.52	1.57	0.77	0.47	0.84

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
99_exp8	ISMAEL_GS	0.00	1.10	1.56	0.37	2.57
ISMAEL_GS	99_exp8	0.01	1.16	0.53	0.17	0.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
99_exp8	99	97	AC091959.3;NT5C1B-RDH14
ISMAEL_GS	14	14