Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
109_exp9	Tier2_GS	9.53e-01	9.19e-01	9.58e-01	1.49e-01
Tier2_GS	109_exp9	3.31e-01	7.07e-01	1.16e-02	9.89e-01



Evaluating how well 109_exp9 genes are linked to Tier2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
109_exp9	Tier2_GS	0.60	-0.92	0.42	0.04	1.95
Tier2_GS	109_exp9	0.50	-0.56	-0.90	-0.37	-0.02

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
109_exp9	Tier2_GS	0.00	-1.14	-0.52	-0.51	0.68
Tier2_GS	109_exp9	0.01	-0.22	-0.88	-0.25	-0.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
109_exp9	109	109	
Tier2_GS	46	43	TNSF13;TNSF12;IGH