Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
109_exp9 Exclusive	GWAS_GS	8.19e-02	4.14e-01	1.17e-01	4.06e-03
GWAS_GS Exclusive	109_exp9	6.25e-01	4.83e-01	1.43e-01	3.75e-01
109_exp9 Exclusive	GWAS_GS Exclusive	8.05e-02	2.80e-01	9.99e-02	6.15e-03
GWAS_GS Exclusive	109_exp9 Exclusive	6.28e-01	6.15e-01	1.26e-01	4.65e-01
109_exp9 Exclusive	Overlap	7.23e-01	5.17e-01	7.52e-01	4.40e-01
GWAS_GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	3.39e-03	1.77e-04	3.61e-48	5.94e-07



Evaluating how well 109_exp9 genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
109_exp9 Exclusive	GWAS_GS	0.59	0.71	0.38	0.87	3.26
GWAS_GS Exclusive	109_exp9	0.52	0.56	0.70	0.58	0.74
109_exp9 Exclusive	GWAS_GS Exclusive	0.59	0.88	0.63	0.78	3.25
GWAS_GS Exclusive	109_exp9 Exclusive	0.52	0.51	0.40	0.48	0.46
109_exp9 Exclusive	Overlap	0.76	-0.10	-1.96	-0.50	1.27
GWAS_GS Exclusive	Overlap	1.00	2.02	1.77	1.98	2.42
Overlap	Exclusives	0.62	5.61	5.91	3.22	6.22

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
109_exp9 Exclusive	GWAS_GS	0.01	0.44	-0.22	0.59	1.12
GWAS_GS Exclusive	109_exp9	0.01	1.70	4.93	2.93	3.77
109_exp9 Exclusive	GWAS_GS Exclusive	0.01	0.40	-0.05	0.38	0.63
GWAS_GS Exclusive	109_exp9 Exclusive	0.01	-0.16	0.81	-0.02	0.31
109_exp9 Exclusive	Overlap	0.00	0.73	0.04	0.79	1.68
GWAS_GS Exclusive	Overlap	0.08	92.54	763.67	173.58	142.47
Overlap	Exclusives	0.06	80.02	70.46	36.09	44.46

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
109_exp9 Exclusive	107	107	
GWAS_GS Exclusive	108	103	MIR302F;PCDH11Y;LINC00158;D21S2088E;SLC8A1-AS1
Overlap	2	2