Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
109_exp9	Ismael_GS	5.57e-01	8.18e-01	3.43e-01	2.55e-02
Ismael_GS	109_exp9	2.20e-03	5.99e-01	8.39e-05	6.54e-01



Evaluating how well 109_exp9 genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
109_exp9	Ismael_GS	0.65	-0.23	-0.58	0.00	1.75
Ismael_GS	109_exp9	0.50	0.11	-0.42	0.09	0.17

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
109_exp9	Ismael_GS	0.00	-0.37	-0.59	-0.19	1.43
Ismael_GS	109_exp9	0.01	-0.17	-0.48	-0.13	-0.18

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
109_exp9	109	109	
Ismael_GS	14	14