Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) 109_exp9 Ismael_GS 5.57e-01 8.18e-01 3.43e-01 2.55e-02 Ismael_GS 109_exp9 2.20e-03 5.99e-01 8.39e-05 6.54e-01 Evaluating how well 109_exp9 genes are linked to Ismael_GS genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 109_exp9 Ismael_GS 0.65 -0.23 -0.58 0.00 1.75 Ismael_GS 109_exp9 0.50 0.11 -0.42 0.09 0.17 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 109_exp9 Ismael_GS 0.00 -0.37 -0.59 -0.19 1.43 Ismael_GS 109_exp9 0.01 -0.17 -0.48 -0.13 -0.18 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes 109_exp9 109 109 Ismael_GS 14 14