Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
125_exp10 Exclusive	Tier1_GS	2.32e-01	9.20e-01	4.12e-01	6.65e-02
Tier1_GS Exclusive	125_exp10	1.98e-01	3.55e-01	2.51e-01	4.43e-01
125_exp10 Exclusive	Tier1_GS Exclusive	4.12e-01	9.70e-01	6.22e-01	1.82e-01
Tier1_GS Exclusive	125_exp10 Exclusive	2.09e-01	4.08e-01	5.49e-01	7.11e-01
125_exp10 Exclusive	Overlap	1.45e-01	7.67e-01	1.70e-01	1.07e-01
Tier1_GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	1.33e-04	9.82e-05	2.02e-15	4.09e-05



Evaluating how well 125_exp10 genes are linked to Tier1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
125_exp10 Exclusive	Tier1_GS	0.62	0.71	0.06	0.34	2.44
Tier1_GS Exclusive	125_exp10	0.53	0.62	1.43	1.57	0.95
125_exp10 Exclusive	Tier1_GS Exclusive	0.60	0.68	0.12	0.37	1.70
Tier1_GS Exclusive	125_exp10 Exclusive	0.52	0.54	1.22	0.81	0.57
125_exp10 Exclusive	Overlap	0.82	1.55	0.88	1.24	2.02
Tier1_GS Exclusive	Overlap	1.00	3.29	2.91	2.99	3.11
Overlap	Exclusives	0.58	4.30	4.08	3.01	3.53

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
125_exp10 Exclusive	Tier1_GS	0.00	1.45	0.52	0.71	1.88
Tier1_GS Exclusive	125_exp10	0.01	1.45	5.43	2.67	4.31
125_exp10 Exclusive	Tier1_GS Exclusive	0.00	0.40	0.34	0.26	0.96
Tier1_GS Exclusive	125_exp10 Exclusive	0.01	0.02	1.30	0.34	0.36
125_exp10 Exclusive	Overlap	0.00	3.26	0.28	2.57	0.30
Tier1_GS Exclusive	Overlap	0.06	141.57	215.82	343.79	213.65
Overlap	Exclusives	0.05	40.47	82.18	44.25	64.58

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
125_exp10 Exclusive	122	121	NT5C1B-RDH14
Tier1_GS Exclusive	28	27	MS4A
Overlap	3	3