Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
125_exp10	Tier2_GS	4.92e-01	5.91e-01	3.13e-01	2.64e-02
Tier2_GS	125_exp10	4.06e-01	6.08e-01	1.54e-02	6.02e-01



Evaluating how well 125_exp10 genes are linked to Tier2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
125_exp10	Tier2_GS	0.64	0.66	1.15	0.88	3.51
Tier2_GS	125_exp10	0.52	0.24	0.40	0.52	0.53

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
125_exp10	Tier2_GS	0.01	2.14	2.52	2.45	7.81
Tier2_GS	125_exp10	0.02	13.48	17.23	6.71	14.62

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
125_exp10	125	124	NT5C1B-RDH14
Tier2_GS	46	43	TNSF13;IGH;TNSF12