Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
125_exp10 Exclusive	GWAS_GS	4.72e-02	1.64e-01	7.23e-02	6.52e-03
GWAS_GS Exclusive	125_exp10	2.06e-01	2.92e-01	3.19e-02	1.99e-01
125_exp10 Exclusive	GWAS_GS Exclusive	7.42e-02	2.24e-01	8.08e-02	1.02e-02
GWAS_GS Exclusive	125_exp10 Exclusive	4.30e-01	4.38e-01	9.12e-02	3.12e-01
125_exp10 Exclusive	Overlap	1.36e-01	7.49e-01	2.35e-01	1.15e-01
GWAS_GS Exclusive	Overlap	4.36e-07	4.36e-07	4.36e-07	4.36e-07
Overlap	Exclusives	2.02e-05	1.96e-05	2.74e-26	4.65e-06



Evaluating how well 125_exp10 genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
125_exp10 Exclusive	GWAS_GS	0.61	1.54	1.42	1.51	4.01
GWAS_GS Exclusive	125_exp10	0.53	1.00	1.47	1.32	1.20
125_exp10 Exclusive	GWAS_GS Exclusive	0.60	1.56	1.40	1.35	3.82
GWAS_GS Exclusive	125_exp10 Exclusive	0.52	0.64	0.84	0.70	0.79
125_exp10 Exclusive	Overlap	0.82	1.49	0.92	0.95	1.88
GWAS_GS Exclusive	Overlap	1.00	2.67	2.55	2.65	3.33
Overlap	Exclusives	0.61	5.45	5.53	3.21	6.03

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
125_exp10 Exclusive	GWAS_GS	0.01	2.47	2.65	2.77	4.34
GWAS_GS Exclusive	125_exp10	0.01	6.29	12.76	9.47	6.58
125_exp10 Exclusive	GWAS_GS Exclusive	0.01	2.36	2.32	2.41	4.42
GWAS_GS Exclusive	125_exp10 Exclusive	0.01	0.77	3.29	1.55	1.51
125_exp10 Exclusive	Overlap	0.00	6.07	0.24	2.39	4.03
GWAS_GS Exclusive	Overlap	0.12	185.58	718.27	347.56	123.09
Overlap	Exclusives	0.06	50.86	66.31	37.96	64.09

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
125_exp10 Exclusive	122	121	NT5C1B-RDH14
GWAS_GS Exclusive	107	102	MIR302F;SLC8A1-AS1;D21S2088E;LINC00158;PCDH11Y
Overlap	3	3