Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
125_exp10	Ismael_GS	1.88e-01	6.93e-01	1.55e-01	1.92e-02
Ismael_GS	125_exp10	2.52e-01	2.81e-01	5.03e-04	1.97e-01



Evaluating how well 125_exp10 genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
125_exp10	Ismael_GS	0.70	0.62	0.59	0.66	2.70
Ismael_GS	125_exp10	0.52	1.29	1.18	1.23	0.99

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
125_exp10	Ismael_GS	0.00	0.77	1.06	0.84	3.80
Ismael_GS	125_exp10	0.01	0.84	0.80	0.76	0.25

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
125_exp10	125	124	NT5C1B-RDH14
Ismael_GS	14	14