Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
76_exp11 Exclusive	Tier1_GS	5.07e-09	2.71e-09	2.30e-08	1.12e-09
Tier1_GS Exclusive	76_exp11	1.34e-01	1.02e-01	6.41e-02	4.11e-02
76_exp11 Exclusive	Tier1_GS Exclusive	1.80e-08	6.45e-09	5.49e-08	2.05e-08
Tier1_GS Exclusive	76_exp11 Exclusive	2.87e-01	1.18e-01	8.54e-02	1.49e-01
76_exp11 Exclusive	Overlap	8.97e-03	5.17e-01	1.18e-02	4.43e-03
Tier1_GS Exclusive	Overlap	9.85e-05	9.85e-05	9.85e-05	9.85e-05
Overlap	Exclusives	7.96e-06	3.62e-09	3.63e-26	4.12e-09



Evaluating how well 76_exp11 genes are linked to Tier1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
76_exp11 Exclusive	Tier1_GS	0.83	4.31	5.89	3.51	6.02
Tier1_GS Exclusive	76_exp11	0.59	3.49	3.08	2.32	2.56
76_exp11 Exclusive	Tier1_GS Exclusive	0.82	4.06	6.38	3.39	5.68
Tier1_GS Exclusive	76_exp11 Exclusive	0.58	3.09	2.82	2.35	2.33
76_exp11 Exclusive	Overlap	0.98	2.47	2.03	2.35	2.31
Tier1_GS Exclusive	Overlap	1.00	3.51	1.78	2.63	2.32
Overlap	Exclusives	0.68	4.26	7.80	3.36	6.37

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
76_exp11 Exclusive	Tier1_GS	0.02	34.36	40.44	18.84	5.09
Tier1_GS Exclusive	76_exp11	0.02	36.24	43.10	32.61	30.29
76_exp11 Exclusive	Tier1_GS Exclusive	0.02	30.43	31.76	13.18	37.43
Tier1_GS Exclusive	76_exp11 Exclusive	0.02	36.88	33.77	7.60	17.97
76_exp11 Exclusive	Overlap	0.01	14.00	9.14	16.32	14.40
Tier1_GS Exclusive	Overlap	0.07	299.09	124.95	256.33	190.05
Overlap	Exclusives	0.09	38.40	172.00	62.65	167.70

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
76_exp11 Exclusive	74	73	AC091959.3
Tier1_GS Exclusive	29	28	MS4A
Overlap	2	2