Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
76_exp11	Tier2_GS	6.76e-01	1.88e-01	4.06e-01	4.11e-02
Tier2_GS	76_exp11	5.12e-01	7.58e-01	2.71e-02	5.15e-01



Evaluating how well 76_exp11 genes are linked to Tier2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
76_exp11	Tier2_GS	0.64	0.62	1.89	1.14	3.19
Tier2_GS	76_exp11	0.54	1.22	0.71	0.79	0.83

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
76_exp11	Tier2_GS	0.01	2.71	5.39	2.64	5.53
Tier2_GS	76_exp11	0.01	5.83	0.43	3.33	3.94

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
76_exp11	76	75	AC091959.3
Tier2_GS	46	43	IGH;TNSF12;TNSF13