Comparing distributions of experimental and random diffusion values (p-values for KS tests) Seeds Recipients Randomize Seeds (degree-matched) Randomize Recipients (degree-matched) Randomize Seeds (uniform) Randomize Recipients (uniform) 76_exp11 Tier2_GS 6.76e-01 1.88e-01 4.06e-01 4.11e-02 Tier2_GS 76_exp11 5.12e-01 7.58e-01 2.71e-02 5.15e-01 Evaluating how well 76_exp11 genes are linked to Tier2_GS genes, comparing against random ROC results Seeds Recipients AUROC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 76_exp11 Tier2_GS 0.64 0.62 1.89 1.14 3.19 Tier2_GS 76_exp11 0.54 1.22 0.71 0.79 0.83 PRC results Seeds Recipients AUPRC Z-score for Random Seeds (degree-matched) Z-score for Random Recipients (degree-matched) Z-score for Random Seeds (uniform) Z-score for Random Recipients (uniform) 76_exp11 Tier2_GS 0.01 2.71 5.39 2.64 5.53 Tier2_GS 76_exp11 0.01 5.83 0.43 3.33 3.94 Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves Seeds: Genes where diffusion signal starts FROM) Recipients: Genes that receive the diffusion signal and that are in the other validated group Random genes are selected either uniformly or degree matched Number of genes ** #Total # Mapped in the network Not mapped genes 76_exp11 76 75 AC091959.3 Tier2_GS 46 43 IGH;TNSF12;TNSF13