Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
76_exp11 Exclusive	GWAS_GS	3.71e-08	5.11e-08	1.98e-08	1.77e-12
GWAS_GS Exclusive	76_exp11	3.88e-02	1.09e-01	5.71e-03	4.91e-02
76_exp11 Exclusive	GWAS_GS Exclusive	1.12e-07	2.60e-08	2.32e-07	9.44e-12
GWAS_GS Exclusive	76_exp11 Exclusive	1.26e-01	1.27e-01	3.59e-02	9.47e-02
76_exp11 Exclusive	Overlap	9.71e-02	2.16e-01	1.11e-01	2.09e-02
GWAS_GS Exclusive	Overlap	3.06e-02	7.71e-02	5.38e-03	4.64e-03
Overlap	Exclusives	2.88e-06	1.76e-08	1.08e-27	2.90e-12



Evaluating how well 76_exp11 genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
76_exp11 Exclusive	GWAS_GS	0.71	5.31	6.50	4.42	7.26
GWAS_GS Exclusive	76_exp11	0.59	3.20	2.96	2.82	2.85
76_exp11 Exclusive	GWAS_GS Exclusive	0.70	5.65	6.80	5.30	6.95
GWAS_GS Exclusive	76_exp11 Exclusive	0.57	2.74	2.68	2.18	2.02
76_exp11 Exclusive	Overlap	0.92	2.58	2.46	2.31	2.78
GWAS_GS Exclusive	Overlap	0.96	3.24	2.27	2.59	2.58
Overlap	Exclusives	0.67	5.80	7.28	3.40	7.26

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
76_exp11 Exclusive	GWAS_GS	0.02	16.93	23.16	17.80	23.19
GWAS_GS Exclusive	76_exp11	0.03	50.57	67.56	42.59	48.43
76_exp11 Exclusive	GWAS_GS Exclusive	0.02	19.25	21.92	18.62	14.59
GWAS_GS Exclusive	76_exp11 Exclusive	0.02	30.00	50.70	10.86	32.41
76_exp11 Exclusive	Overlap	0.00	17.77	12.58	10.26	6.98
GWAS_GS Exclusive	Overlap	0.07	190.53	383.74	185.07	45.59
Overlap	Exclusives	0.05	42.82	49.77	25.08	39.98

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
76_exp11 Exclusive	73	72	AC091959.3
GWAS_GS Exclusive	107	102	SLC8A1-AS1;PCDH11Y;LINC00158;MIR302F;D21S2088E
Overlap	3	3