Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
76_Exp11	Ismael_GS	5.24e-02	5.77e-03	2.68e-02	3.96e-03
Ismael_GS	76_Exp11	1.50e-01	1.03e-01	1.10e-05	1.89e-02



Evaluating how well 76_Exp11 genes are linked to Ismael_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
76_Exp11	Ismael_GS	0.81	1.95	3.80	1.86	3.90
Ismael_GS	76_Exp11	0.59	4.53	3.22	2.75	2.60

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
76_Exp11	Ismael_GS	0.00	5.30	8.38	6.22	3.58
Ismael_GS	76_Exp11	0.01	2.91	3.92	0.99	2.83

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
76_Exp11	76	75	AC091959.3
Ismael_GS	14	14