Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
94_exp12 Exclusive	tier1_GS	6.42e-01	8.51e-01	5.99e-01	5.62e-01
tier1_GS Exclusive	94_exp12	1.28e-01	3.18e-01	1.49e-01	1.89e-01
94_exp12 Exclusive	tier1_GS Exclusive	6.64e-01	6.86e-01	6.61e-01	7.26e-01
tier1_GS Exclusive	94_exp12 Exclusive	1.57e-01	2.42e-01	1.49e-01	1.57e-01
94_exp12 Exclusive	Overlap	2.38e-01	1.98e-02	2.57e-01	9.90e-02
tier1_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	6.49e-04	3.47e-04	2.64e-35	3.07e-04



Evaluating how well 94_exp12 genes are linked to tier1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
94_exp12 Exclusive	tier1_GS	0.57	-0.25	-0.41	-0.32	1.39
tier1_GS Exclusive	94_exp12	0.53	0.47	0.88	0.70	1.03
94_exp12 Exclusive	tier1_GS Exclusive	0.56	-0.34	-0.52	-0.35	0.86
tier1_GS Exclusive	94_exp12 Exclusive	0.52	0.51	0.86	1.04	0.90
94_exp12 Exclusive	Overlap	0.97	0.80	81649676361157.50	0.96	1.56
tier1_GS Exclusive	Overlap	1.00	1.27	inf	1.76	1.75
Overlap	Exclusives	0.61	inf	4.38	2.14	4.32

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
94_exp12 Exclusive	tier1_GS	0.00	-0.10	-0.45	-0.18	0.20
tier1_GS Exclusive	94_exp12	0.01	-0.07	0.70	0.21	0.31
94_exp12 Exclusive	tier1_GS Exclusive	0.00	-0.32	-0.42	-0.25	-0.08
tier1_GS Exclusive	94_exp12 Exclusive	0.01	-0.22	0.19	0.20	0.17
94_exp12 Exclusive	Overlap	0.00	0.40	1553880573510938.00	0.65	1.70
tier1_GS Exclusive	Overlap	0.02	19.43	151272923003761312.00	71.58	11.27
Overlap	Exclusives	0.02	9710611082086740.00	28.83	10.11	27.66

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
94_exp12 Exclusive	93	93	
tier1_GS Exclusive	30	29	MS4A
Overlap	1	1