Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
94_exp12 Exclusive	GWAS_GS	5.58e-01	5.83e-01	6.18e-01	1.45e-02
GWAS_GS Exclusive	94_exp12	4.14e-01	7.98e-01	2.94e-01	5.79e-01
94_exp12 Exclusive	GWAS_GS Exclusive	5.09e-01	6.54e-01	4.59e-01	2.40e-02
GWAS_GS Exclusive	94_exp12 Exclusive	4.31e-01	8.88e-01	3.36e-01	8.70e-01
94_exp12 Exclusive	Overlap	1.98e-01	1.98e-02	1.98e-01	3.96e-02
GWAS_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	2.05e-04	1.27e-04	8.99e-58	9.87e-07



Evaluating how well 94_exp12 genes are linked to GWAS_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
94_exp12 Exclusive	GWAS_GS	0.58	0.54	0.68	0.51	3.34
GWAS_GS Exclusive	94_exp12	0.52	0.48	0.24	0.40	0.76
94_exp12 Exclusive	GWAS_GS Exclusive	0.58	0.66	0.60	0.62	2.63
GWAS_GS Exclusive	94_exp12 Exclusive	0.51	0.44	0.25	0.37	0.38
94_exp12 Exclusive	Overlap	0.97	0.93	81649676361157.50	0.86	1.69
GWAS_GS Exclusive	Overlap	1.00	1.11	98784710366980.00	1.20	1.79
Overlap	Exclusives	0.63	inf	5.61	2.31	6.06

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
94_exp12 Exclusive	GWAS_GS	0.01	0.18	0.45	0.36	0.77
GWAS_GS Exclusive	94_exp12	0.01	2.65	2.62	0.46	1.22
94_exp12 Exclusive	GWAS_GS Exclusive	0.01	0.20	0.32	0.44	1.87
GWAS_GS Exclusive	94_exp12 Exclusive	0.01	0.16	1.09	0.31	0.21
94_exp12 Exclusive	Overlap	0.00	0.91	1553880573510938.00	0.24	4.17
GWAS_GS Exclusive	Overlap	0.04	31.75	inf	31.67	310.80
Overlap	Exclusives	0.03	9629376397382438.00	24.84	9.69	23.82

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
94_exp12 Exclusive	93	93	
GWAS_GS Exclusive	109	104	SLC8A1-AS1;MIR302F;LINC00158;PCDH11Y;D21S2088E
Overlap	1	1