Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
91_exp13 Exclusive	Tier1_GS	1.26e-01	6.40e-02	1.72e-01	3.12e-03
Tier1_GS Exclusive	91_exp13	8.12e-01	9.65e-01	7.03e-01	9.38e-01
91_exp13 Exclusive	Tier1_GS Exclusive	1.09e-01	6.33e-02	2.47e-01	3.54e-03
Tier1_GS Exclusive	91_exp13 Exclusive	7.18e-01	9.24e-01	7.07e-01	9.47e-01
91_exp13 Exclusive	Overlap	3.56e-01	1.98e-02	7.33e-01	1.98e-01
Tier1_GS Exclusive	Overlap	1.98e-02	1.98e-02	1.98e-02	1.98e-02
Overlap	Exclusives	2.46e-04	4.01e-03	3.17e-35	4.31e-03



Evaluating how well 91_exp13 genes are linked to Tier1_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
91_exp13 Exclusive	Tier1_GS	0.64	0.97	1.59	0.83	2.59
Tier1_GS Exclusive	91_exp13	0.52	0.95	0.72	0.98	0.75
91_exp13 Exclusive	Tier1_GS Exclusive	0.63	1.08	1.55	0.75	2.31
Tier1_GS Exclusive	91_exp13 Exclusive	0.52	0.84	0.73	0.89	0.47
91_exp13 Exclusive	Overlap	0.93	0.82	641633707883306.00	0.59	1.49
Tier1_GS Exclusive	Overlap	1.00	1.20	inf	1.67	1.76
Overlap	Exclusives	0.58	inf	3.47	2.01	3.23

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
91_exp13 Exclusive	Tier1_GS	0.00	0.29	0.28	0.02	0.81
Tier1_GS Exclusive	91_exp13	0.01	0.37	1.39	1.18	1.84
91_exp13 Exclusive	Tier1_GS Exclusive	0.00	0.38	0.01	0.02	0.72
Tier1_GS Exclusive	91_exp13 Exclusive	0.01	0.31	0.69	0.41	0.20
91_exp13 Exclusive	Overlap	0.00	0.20	5005571383055780.00	-0.19	0.28
Tier1_GS Exclusive	Overlap	0.02	13.36	151272923003761312.00	50.38	103.31
Overlap	Exclusives	0.02	inf	27.18	18.07	24.83

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
91_exp13 Exclusive	90	90	
Tier1_GS Exclusive	30	29	MS4A
Overlap	1	1