Comparing distributions of experimental and random diffusion values (p-values for KS tests)
Seeds	Recipients	Randomize Seeds (degree-matched)	Randomize Recipients (degree-matched)	Randomize Seeds (uniform)	Randomize Recipients (uniform)
91_exp13	Tier2_GS	6.99e-01	5.78e-01	8.59e-01	8.35e-02
Tier2_GS	91_exp13	1.54e-01	6.45e-01	5.96e-02	7.52e-01



Evaluating how well 91_exp13 genes are linked to Tier2_GS genes, comparing against random

ROC results
Seeds	Recipients	AUROC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
91_exp13	Tier2_GS	0.58	-0.98	-0.81	-0.39	1.87
Tier2_GS	91_exp13	0.49	-0.80	-0.66	-0.38	-0.15

PRC results
Seeds	Recipients	AUPRC	Z-score for Random Seeds (degree-matched)	Z-score for Random Recipients (degree-matched)	Z-score for Random Seeds (uniform)	Z-score for Random Recipients (uniform)
91_exp13	Tier2_GS	0.00	-0.41	-0.53	-0.15	0.90
Tier2_GS	91_exp13	0.00	-0.54	-0.58	-0.16	-0.06

Z-scores are computed for the experimental area under ROC or PRC based on distributions of the random areas under these curves
Seeds: Genes where diffusion signal starts FROM)
Recipients: Genes that receive the diffusion signal and that are in the other validated group
Random genes are selected either uniformly or degree matched



Number of genes
**	#Total	# Mapped in the network	Not mapped genes	 
91_exp13	91	91	
Tier2_GS	46	43	TNSF13;IGH;TNSF12